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Title: | Tracing cross species transmission of Mycobacterium bovis at the wildlife/ livestock interface in South Africa | Authors: | Sichewo, Petronillah R. Hlokwe, Tiny M. Etter, Eric M. C. Miche, Anita L. |
Keywords: | African buffalo Bovine tuberculosis (bTB) Mycobacterium bovis (M. bovis) Wildlife/ livestock interface strains wildlife |
Issue Date: | 2020 | Publisher: | BioMed Central Ltd. | Series/Report no.: | BMC Microbiology;Vol.20 ; No.49 | Abstract: | Background: Bovine tuberculosis (bTB) affects cattle and wildlife in South Africa with the African buffalo (Syncerus caffer) as the principal maintenance host. The presence of a wildlife maintenance host at the wildlife/livestock interface acting as spill-over host makes it much more challenging to control and eradicate bTB in cattle. Spoligotyping and mycobacterial interspersed repetitive unit-variable number of tandem repeat (MIRU-VNTR) genotyping methods were performed to investigate the genetic diversity of Mycobacterium bovis (M. bovis) isolates from cattle and wildlife, their distribution and transmission at the wildlife/livestock interface in northern Kwa-Zulu Natal (KZN), South Africa. Results: SB0130 was identified as the dominant spoligotype pattern at this wildlife/livestock interface, while VNTR typing revealed a total of 29 VNTR profiles (strains) in the KZN province signifying high genetic variability. The detection of 5 VNTR profiles shared between cattle and buffalo suggests M. bovis transmission between species. MIRU-VNTR confirmed co-infection in one cow with three strains of M. bovis that differed at a single locus, with 2 being shared with buffalo, implying pathogen introduction from most probably unrelated wildlife sources. Conclusion: Our findings highlight inter and intra species transmission of bTB at the wildlife/livestock interface and the need for the implementation of adequate bTB control measures to mitigate the spread of the pathogen responsible for economic losses and a public health threat. | URI: | http://hdl.handle.net/11408/4233 | ISSN: | 1471-2180 |
Appears in Collections: | Research Papers |
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