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DC Field | Value | Language |
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dc.contributor.author | Sichewo, Petronillah R. | - |
dc.contributor.author | Hlokwe, Tiny M. | - |
dc.contributor.author | Etter, Eric M. C. | - |
dc.contributor.author | Miche, Anita L. | - |
dc.date.accessioned | 2021-05-24T07:27:33Z | - |
dc.date.available | 2021-05-24T07:27:33Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1471-2180 | - |
dc.identifier.uri | http://hdl.handle.net/11408/4233 | - |
dc.description.abstract | Background: Bovine tuberculosis (bTB) affects cattle and wildlife in South Africa with the African buffalo (Syncerus caffer) as the principal maintenance host. The presence of a wildlife maintenance host at the wildlife/livestock interface acting as spill-over host makes it much more challenging to control and eradicate bTB in cattle. Spoligotyping and mycobacterial interspersed repetitive unit-variable number of tandem repeat (MIRU-VNTR) genotyping methods were performed to investigate the genetic diversity of Mycobacterium bovis (M. bovis) isolates from cattle and wildlife, their distribution and transmission at the wildlife/livestock interface in northern Kwa-Zulu Natal (KZN), South Africa. Results: SB0130 was identified as the dominant spoligotype pattern at this wildlife/livestock interface, while VNTR typing revealed a total of 29 VNTR profiles (strains) in the KZN province signifying high genetic variability. The detection of 5 VNTR profiles shared between cattle and buffalo suggests M. bovis transmission between species. MIRU-VNTR confirmed co-infection in one cow with three strains of M. bovis that differed at a single locus, with 2 being shared with buffalo, implying pathogen introduction from most probably unrelated wildlife sources. Conclusion: Our findings highlight inter and intra species transmission of bTB at the wildlife/livestock interface and the need for the implementation of adequate bTB control measures to mitigate the spread of the pathogen responsible for economic losses and a public health threat. | en_US |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central Ltd. | en_US |
dc.relation.ispartofseries | BMC Microbiology;Vol.20 ; No.49 | - |
dc.subject | African buffalo | en_US |
dc.subject | Bovine tuberculosis (bTB) | en_US |
dc.subject | Mycobacterium bovis (M. bovis) | en_US |
dc.subject | Wildlife/ livestock interface | en_US |
dc.subject | strains | en_US |
dc.subject | wildlife | en_US |
dc.title | Tracing cross species transmission of Mycobacterium bovis at the wildlife/ livestock interface in South Africa | en_US |
dc.type | Article | en_US |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
Appears in Collections: | Research Papers |
Files in This Item:
File | Description | Size | Format | |
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sichewo.pdf | Article | 810.16 kB | Adobe PDF | View/Open |
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