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https://cris.library.msu.ac.zw//handle/11408/4224
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DC Field | Value | Language |
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dc.contributor.author | von Dadelszen, Peter | - |
dc.contributor.author | Flint-O’Kane, Meriel | - |
dc.contributor.author | Poston, Lucilla | - |
dc.contributor.author | Craik, Rachel | - |
dc.contributor.author | Russell, Donna | - |
dc.contributor.author | Tribe, Rachel M. | - |
dc.contributor.author | d’Alessandro, Umberto | - |
dc.contributor.author | Roca, Anna | - |
dc.contributor.author | Jah, Hawanatu | - |
dc.contributor.author | Temmerman, Marleen | - |
dc.contributor.author | Etyang, Angela Koech | - |
dc.contributor.author | Sevene, Esperança | - |
dc.contributor.author | Chin, Paulo | - |
dc.contributor.author | Lawn, Joy E. | - |
dc.contributor.author | Blencowe, Hannah | - |
dc.contributor.author | Sandall, Jane | - |
dc.contributor.author | Salisbury, Tatiana T. | - |
dc.contributor.author | Barratt, Benjamin | - |
dc.contributor.author | Shennan, Andrew H. | - |
dc.contributor.author | Makanga, Prestige Tatenda | - |
dc.contributor.author | Magee, Laura A. | - |
dc.contributor.author | PRECISE Network | - |
dc.date.accessioned | 2021-05-21T09:17:38Z | - |
dc.date.available | 2021-05-21T09:17:38Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1742-4755 | - |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191688/pdf/12978_2020_Article_872.pdf | - |
dc.identifier.uri | http://hdl.handle.net/11408/4224 | - |
dc.description.abstract | Background: The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network is a new and broadly-based group of research scientists and health advocates based in the UK, Africa and North America. Methods: This paper describes the protocol that underpins the clinical research activity of the Network, so that the investigators, and broader global health community, can have access to ‘deep phenotyping’ (social determinants of health, demographic and clinical parameters, placental biology and agnostic discovery biology) of women as they advance through pregnancy to the end of the puerperium, whether those pregnancies have normal outcomes or are complicated by one/more of the placental disorders of pregnancy (pregnancy hypertension, fetal growth restriction and stillbirth). Our clinical sites are in The Gambia (Farafenni), Kenya (Kilifi County), and Mozambique (Maputo Province). In each country, 50 non-pregnant women of reproductive age will be recruited each month for 1 year, to provide a final national sample size of 600; these women will provide culturally-, ethnically-, seasonally and spatially-relevant control data with which to compare women with normal and complicated pregnancies. Between the three countries we will recruit ≈10,000 unselected pregnant women over 2 years. An estimated 1500 women will experience one/more placental complications over the same epoch. Importantly, as we will have accurate gestational age dating using the TraCer device, we will be able to discriminate between fetal growth restriction and preterm birth. Recruitment and follow-up will be primarily facility-based and will include women booking for antenatal care, subsequent visits in the third trimester, at time-of-disease, when relevant, during/ immediately after birth and 6 weeks after birth. | en_US |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central Ltd. | en_US |
dc.relation.ispartofseries | Reproductive Health;Vol.17 ; No.51 | - |
dc.subject | Pregnancy | en_US |
dc.subject | Africa south of the Sahara | en_US |
dc.subject | Biorepository | en_US |
dc.subject | Biological specimens | en_US |
dc.subject | Pre-eclampsia | en_US |
dc.title | The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network’s first protocol: deep phenotyping in three sub-Saharan African countries | en_US |
dc.type | Article | en_US |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | Research Papers |
Files in This Item:
File | Description | Size | Format | |
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makanga.pdf | Article | 1.94 MB | Adobe PDF | View/Open |
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