| Title: | The PRECISE-DYAD protocol: linking maternal and infant health trajectories in sub-Saharan Africa |
Authors: | Rachel Craik
Marie-Laure Volvert
Angela Koech
Hawanatu Jah
Kelly Pickerill
Amina Abubakar
Umberto D’Alessandro
Benjamin Barratt
Hannah Blencowe
Jeffrey N Bone
Jaya Chandna
Melissa J. Gladstone
Asma Khalil
Larry Li
Laura A Magee
Liberty Makacha
Hiten D Mistry
Sophie E. Moore
Anna Roca
Tatiana T Salisbury
Marleen Temmerman
Danielle Toudup
Marianne Vidler
Peter von Dadelszen
The PRECISE-DYAD Network
Department of Women and Children’s Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK
Department of Women and Children’s Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK
Centre of Excellence Women and Child Health, Aga Khan University, Nairobi, Kenya
Centre of Excellence Women and Child Health, Aga Khan University, Nairobi, Kenya
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
Institute for Human Development, Aga Khan University, Nairobi, Kenya
Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia
MRC Centre for Environment and Health, Imperial College London, London, UK
London School of Hygiene and Tropical Medicine, London, UK
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
London School of Hygiene and Tropical Medicine, London, UK
Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK
Fetal Medicine Unit, Department of Obstetrics and Gynaecology, St. George's University Hospitals NHS Foundation Trust, London, UK; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
Department of Women and Children’s Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK
Department of Women and Children’s Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK; MRC Centre for Environment and Health, Imperial College London, London, UK; Department of Surveying and Geomatics, Midlands State University, Gweru, Zimbabwe
Department of Women and Children’s Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK
Department of Women and Children’s Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK
Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia
Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Centre of Excellence Women and Child Health, Aga Khan University, Nairobi, Kenya
Medical School, University of Sheffield, Sheffield, UK
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
Department of Women and Children’s Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK
#PLACEHOLDER_PARENT_METADATA_VALUE# |
Keywords: | PRECISE-DYAD
mother-child dyads
maternal and infant health
sub-Saharan Africa |
Issue Date: | Apr-2024 |
Publisher: | Taylor and Francis
F1000Research |
Abstract: | Background
PRECISE-DYAD is an observational cohort study of mother-child dyads running in urban and rural communities in The Gambia and Kenya. The cohort is being followed for two years and includes uncomplicated pregnancies and those that suffered pregnancy hypertension, fetal growth restriction, preterm birth, and/or stillbirth.
Methods
The PRECISE-DYAD study will follow up ~4200 women and their children recruited into the original PRECISE study. The study will add to the detailed pregnancy information and samples in PRECISE, collecting additional biological samples and clinical information on both the maternal and child health.
Women will be asked about both their and their child’s health, their diets as well as undertaking a basic cardiology assessment. Using a case-control approach, some mothers will be asked about their mental health, their experiences of care during labour in the healthcare facility. In a sub-group, data on financial expenditure during antenatal, intrapartum, and postnatal periods will also be collected. Child development will be assessed using a range of tools, including neurodevelopment assessments, and evaluating their home environment and quality of life. In the event developmental milestones are not met, additional assessments to assess vision and their risk of autism spectrum disorders will be conducted. Finally, a personal environmental exposure model for the full cohort will be created based on air and water quality data, combined with geographical, demographic, and behavioural variables.
Conclusions
The PRECISE-DYAD study will provide a greater epidemiological and mechanistic understanding of health and disease pathways in two sub-Saharan African countries, following healthy and complicated pregnancies. We are seeking additional funding to maintain this cohort and to gain an understanding of the effects of pregnancies outcome on longer-term health trajectories in mothers and their children. |
URI: | https://cris.library.msu.ac.zw//handle/11408/6289 |
| Appears in Collections: | Research Papers
|
