Please use this identifier to cite or link to this item: https://cris.library.msu.ac.zw//handle/11408/4686
Title: A mathematical model for the prediction of the prevalence of allergies in Zimbabwe
Authors: Mushayi, Caroline
Nyabadza, Farai
Chigidi, Esther
Mataramvura, Hope
Pfavayi, Lorraine
Rusakaniko, Simbarashe
Sibanda, Elopy Nimele
Keywords: Food allergy
Inhalant allergy
Mathematical model
Zimbabwe
Issue Date: 2021
Publisher: Elsevier
Series/Report no.: World Allergy Organization Journal;Vol. 2; No. 7
Abstract: Background The prevalence of allergies has been observed to be increasing in the past years in Zimbabwe. It is thus important to consider the long term prevalence of allergies. Our interest is in investigating the trends of allergies in the next 2 decades. Method We formulate a deterministic model with 6 compartments to predict the prevalence of allergies in Zimbabwe. The human population is divided into 4 distinct epidemiological, classes based on their exposure to 2 allergen groups (food and inhalants), represented by 2 compartments. The model is used to predict the prevalence of allergen sensitization. The number of human allergen groups in each compartment are tracked through a system of differential equations. Model parameters were obtained by fitting observed data to the model. Graphical solutions of the model were developed using Matlab and Excel. Results The rate of sensitisation to food allergen sources is found to be lower than the rate of sensitisation to inhalant allergens. The rate at which individuals develop tolerance to food allergen sources is found to be almost twice the rate of developing tolerance to inhalant allergies. The equilibrium solutions (the long-term states of the populations) of the model are found to be non-zero implying that there will never be an allergy-free population. Our results also show that the prevalence of food allergy is likely to increase in the next 2 decades while inhalant allergy prevalence is expected to decrease. Conclusion Our long-term solutions show endemicity in allergies in Zimbabwe. So, allergy will be endemic in the Zimbabwean population; hence there is a need for allergy care and management facilities to be increased. These results are critical in policy development and planning around allergies in the near future.
URI: https://doi.org/10.1016/j.waojou.2021.100555
http://hdl.handle.net/11408/4686
ISSN: 1939-4551
Appears in Collections:Research Papers

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